Insulin sensitivity in long-living Ames dwarf mice
نویسندگان
چکیده
منابع مشابه
Altered methionine metabolism in long living Ames dwarf mice.
Ames dwarf mice (df/df) are deficient in growth hormone, prolactin, and thyroid-stimulating hormone and live significantly longer than their normal siblings. In the current study, we found that the hormone deficiencies affect methionine metabolism. We previously reported that the dwarf mice exhibit enzyme activities and levels that combat oxidative stress more efficiently than those of normal m...
متن کاملChanges of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging
The Ames dwarf (df/df) mice have extended longevity and can preserve the ovarian reserve longer than Normal (N) mice. Based on this, the aim of our study was to evaluate the ovarian microRNA (miRNA) profile in young and aged df/df and N mice. Ovarian tissue was collected at 5-6 months and at 21-22 months of age for miRNA sequencing. We detected a total of 404 miRNAs in the ovarian samples, from...
متن کاملLong-lived ames dwarf mice are resistant to chemical stressors.
To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwar...
متن کاملMethionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse.
Long-lived Ames dwarf mice lack growth hormone, prolactin, and thyroid stimulating hormone. Additionally the dwarf mice have enzyme activities and levels that combat oxidative stress more efficiently than those of normal mice. We have shown that methionine metabolism in Ames mice is markedly different than in their wild type littermates. In our previous work we hypothesized that the flux of met...
متن کاملEffects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice.
Ames dwarf (Prop1(df), df/df) mice lack growth hormone (GH), prolactin, and thyrotropin and live remarkably longer than their normal siblings. Significance of reduced activity of the somatotropic and thyroid axes during development and adulthood on longevity are unknown. Because enhanced insulin sensitivity and reduced insulin levels are among likely mechanisms responsible for increased longevi...
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ژورنال
عنوان ژورنال: AGE
سال: 2014
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-014-9709-1